Note 11 - Stockholders' Deficit - Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Share-based Payment Arrangement, Expense	$ 32,633	$ 36,575	$ 57,327
Selling, General and Administrative Expenses [Member]
Share-based Payment Arrangement, Expense	13,587	0	0
Selling, General and Administrative Expenses [Member] | Share-based Payment Arrangement, Option [Member]
Share-based Payment Arrangement, Expense	3,873	3,937	9,044
Selling, General and Administrative Expenses [Member] | Restricted Stock Units (RSUs) [Member]
Share-based Payment Arrangement, Expense	8,239	13,841	18,848
Research and Development Expense [Member] | Share-based Payment Arrangement, Option [Member]
Share-based Payment Arrangement, Expense	573	3,018	7,452
Research and Development Expense [Member] | Restricted Stock Units (RSUs) [Member]
Share-based Payment Arrangement, Expense	$ 6,361	$ 15,779	$ 21,983