Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue:
Total revenue	$ 253,155	$ 225,110	$ 272,260
Operating costs and expenses:
Cost of sales	63,701	39,374	36,815
Selling, general and administrative	116,294	118,488	141,639
Research and development	71,870	97,650	132,851
Total operating costs and expenses	251,865	255,512	311,305
Income (1oss) from operations	1,290	(30,402)	(39,045)
Other income (expenses):
Interest income	160	489	2,847
Interest expense	(12,807)	(14,046)	(15,019)
Legal verdict expense	(9,591)	(16,196)	(16,350)
Loss on debt extinguishment	(8,146)	0	(8,103)
Other income	292	367	128
Total other expenses	(30,092)	(29,386)	(36,497)
Loss before income taxes	(28,802)	(59,788)	(75,542)
Income tax expense	(324)	(207)	(53)
Net loss	$ (29,126)	$ (59,995)	$ (75,595)
Net loss applicable to common stockholders (in dollars per share)	$ (29,126)	$ (59,995)	$ (75,595)
Net loss per share of common stock—basic and diluted (in dollars per share)	$ (0.72)	$ (1.52)	$ (1.95)
Weighted-average shares of common stock outstanding—basic and diluted (in shares)	40,638,852	39,576,107	38,768,653
Product [Member]
Revenue:
Total revenue	$ 189,064	$ 196,728	$ 211,619
License [Member]
Revenue:
Total revenue	51,750	22,700	60,250
Royalty [Member]
Revenue:
Total revenue	$ 12,341	$ 5,682	$ 391