X0306 4/A 2021-02-17 2021-02-19 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001727172 HUNT DOUGLAS M C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 2150 LOS ANGELES CA 90024 0 1 0 0 See Remarks COMMON STOCK 2021-02-17 4 A 0 19757 0.00 A 69640 D STOCK OPTION (RIGHT TO BUY) 12.02 2021-02-17 4 A 0 27793 0.00 A 2031-02-16 COMMON STOCK 27793 27793 D Subject to the Grantee's continued service with the Company through the applicable vesting date, the Restricted Stock Units shall vest with respect to (i) one-third (1/3) of the Restricted Stock Units on the first anniversary of the vesting commencement date of January 1, 2021 (the "Vesting Commencement Date") and (ii) one-sixth (1/6th) of the Restricted Stock Units on each of July 1, 2022, January 1, 2023, July 1, 2023 and January 1, 2024. Subject to the Optionee's continued service with the Company through the applicable vesting date, the Option shall vest and become exercisable with respect to (i) one-third (1/3) of the Shares (as defined in the Plan) underlying the Option on the first anniversary of the vesting commencement date of January 1, 2021 (the "Vesting Commencement Date") and (ii) one-sixth (1/6th) of the Shares subject thereto on each of July 1, 2022, January 1, 2023, July 1, 2023, and January 1, 2024. The Reporting Person is the Senior Vice President of Regulatory Affairs of the Issuer. This amended Form 4 is filed solely to correct a typo, relating to the vesting schedules of the Restricted Stock Units and the Options, respectively, in the initial filing. /s/ Douglas M. Hunt 2021-02-24