X0306 4 2019-02-06 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001501959 Lo Steven C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 0 1 0 0 Chief Commercial Officer STOCK OPTION (RIGHT TO BUY) 27.76 2019-02-06 4 A 0 36300 0.00 A 2029-02-05 COMMON STOCK 36300 36300 D The vesting commencement date ("Option Vesting Commencement Date") of the option is January 1, 2019. The option vests (i) with respect to one-third (1/3rd) of the shares underlying the option on the first anniversary of the Option Vesting Commencement Date and (ii) with respect to 1/36th of the shares underlying the option on each monthly anniversary of the Option Vesting Commencement Date thereafter, subject to the Reporting Person's continued service with the Issuer through the applicable vesting date. /s/ Steven Lo 2019-02-08