X0306 4/A 2018-02-11 2018-02-13 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001553037 BRYCE RICHARD PAUL C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 0 1 0 0 SEE REMARKS COMMON STOCK 2018-02-11 4 A 0 9000 0.00 A 34379 D Represents Restricted Stock Units which vest (i) with respect to one-third (1/3rd) of the shares subject thereto on the first anniversary of the vesting commencement date of January 1, 2018 ("Vesting Commencement Date") and (ii) with respect to 1/36th of the shares subject thereto on each monthly anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person's continued service with the Issuer through the applicable vesting date. This amended Form 4 is filed solely for the purpose of correcting an administrative error in column 4 reporting securities as disposed of, instead of acquired, as reported on the Form 4 filed February 13, 2018. Title of Reporting Person: Chief Medical and Scientific Officer /s/ Richard Paul Bryce 2018-03-06