X0306 4 2018-02-23 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001236514 MILLER MICHAEL PATRICK C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 2150 LOS ANGELES CA 90024 1 0 0 0 Stock Option (Right to Buy) 68.25 2018-02-23 4 A 0 17626 0.00 A 2028-02-22 Common Stock 17626 17626 D The vesting commencement date ("Vesting Commencement Date") of the option is February 23, 2018. The option vests (i) with respect to one-third (1/3) of the shares underlying the option on the first anniversary of the Vesting Commencement Date and (ii) with respect to 1/36th of the shares underlying the option, on each monthly anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person's continued service with the Issuer through the applicable vesting date. /s/ Michael Patrick Miller 2018-02-27