X0306 4 2017-07-20 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001358246 EYLER CHARLES R C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 0 1 0 0 SEE REMARKS COMMON STOCK 2017-07-20 4 S 0 662 95.1527 D 30018 D The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 16, 2016 to satisfy tax obligations in connection with the vesting of restricted stock units. The price reported in Column 4 is a weighted average price. The shares were sold in two transactions with one transaction pricing at $95.151 and the other transaction pricing at $95.701. The Reporting Person undertakes to provide to the Issuer, any security holder, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price set forth in this footnote. Title of Reporting Person: Senior Vice President, Finance and Administration and Treasurer /s/ Charles R. Eyler 2017-07-24