X0306 4 2017-02-16 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001501959 Lo Steven C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 0 1 0 0 Chief Commercial Officer STOCK OPTION (RIGHT TO BUY) 37.35 2017-02-16 4 A 0 31500 0.00 A 2027-02-15 COMMON STOCK 31500 31500 D The vesting commencement date ("Vesting Commencement Date") of the option is February 16, 2017. The option vests (i) with respect to one-third (1/3) of the shares underlying the option on the first anniversary of the Vesting Commencement Date and (ii) with respect to 1/36th of the shares underlying the option, on each monthly anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person's continued service with the Issuer; provided, however, that if the Reporting Person experiences a Qualifying Termination (as defined in the letter agreement between the Issuer and the Reporting Person) on or within eighteen (18) months following a Change in Control (as defined in the Issuer's 2011 Incentive Award Plan), then the option shall vest and become exercisable upon the effectiveness of the Release (as defined in the letter agreement). /s/ Steven Lo 2017-02-17