X0306 4 2017-02-01 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001678610 CHARNAS ROBERT C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 2150 LOS ANGELES CA 90024 0 0 0 1 See Remarks COMMON STOCK 2017-02-01 4 S 0 1000 31.80 D 28461 D COMMON STOCK 2017-02-01 4 S 0 2008 31.85 D 26453 D The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 15, 2016. The Reporting Person is the Senior Vice President of Regulatory Affairs and Project Management of the Issuer. /s/ Robert Charnas 2017-02-02