X0306 4/A 2017-01-20 2017-01-24 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001678610 CHARNAS ROBERT C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 2150 LOS ANGELES CA 90024 0 0 0 1 See Remarks COMMON STOCK 2017-01-20 4 S 0 2239 33.2351 D 29461 D The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on December 15, 2016 to satisfy tax obligations in connection with the vesting of restricted stock units. This amended Form 4 is filed solely for the purpose of correcting an administrative error in the number of shares sold originally reported on the Form 4 filed January 24, 2017. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.90 to $33.60, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The Reporting Person is the Senior Vice President of Regulatory Affairs and Project Management of the Issuer. /s/ Robert Charnas 2017-02-02