X0306 4 2022-04-12 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001401650 NBVM GP, LLC 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001206641 DAMORE RICHARD A 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001138402 NORTH BRIDGE VENTURE PARTNERS V A LP 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001138399 NORTH BRIDGE VENTURE PARTNERS V-B LP 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001327539 North Bridge Venture Partners VI L P 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001297397 North Bridge Venture Management V, L.P. 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001590898 North Bridge Venture Management VI, L.P. 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 Common Stock 2022-04-12 4 P 0 1076851 4.22 A 1855443 I See footnote Common Stock 2022-04-12 4 P 0 527806 4.22 A 909424 I See footnote Common Stock 2022-04-12 4 P 0 765010 4.22 A 1318133 I See footnote The reportable securities were acquired pursuant to the Securities Purchase Agreement dated April 7, 2022 between the Issuer, North Bridge Venture Partners V-A, L.P. ("NBVP V-A"), North Bridge Venture Partners V-B, L.P. ("NBVP V-B"), North Bridge Venture Partners VI, L.P. ("NBVP VI") and certain other investors. The reportable securities are owned directly by NBVP V-A. North Bridge Venture Management V, L.P. ("NBVM V") is the sole general partner of NBVP V-A and North Bridge Venture Management GP, LLC ("NBVM GP") is the sole general partner of NBVM V. Each of Edward T. Anderson ("Anderson"), a member of the Issuer's board of directors, and Richard A. D'Amore ("D'Amore") are the managing members of NBVM GP and may be deemed to have shared voting and dispositive power over the shares held by NBVP V-A. Each of NBVM V, NBVM GP, Anderson and D'Amore disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by NBVP V-B. NBVM V is the sole general partner of NBVP V-B and NBVM GP is the sole general partner of NBVM V. Each of Anderson, a member of the Issuer's board of directors, and D'Amore are the managing members of NBVM GP and may be deemed to have shared voting and dispositive power over the shares held by NBVP V-B. Each of NBVM V, NBVM GP, Anderson and D'Amore disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by NBVP VI. North Bridge Venture Management VI, L.P. ("NBVM VI") is the sole general partner of NBVP VI and NBVM GP is the sole general partner of NBVM VI. Each of Anderson, a member of the Issuer's board of directors, and D'Amore are the managing members of NBVM GP and may be deemed to have shared voting and dispositive power over the shares held by NBVP VI. Each of NBVM VI, NBVM GP, Anderson and D'Amore disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. North Bridge Venture Partners V-A, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management V, L.P., general partner of North Bridge Venture Partners V-A, L.P. 2022-04-14 North Bridge Venture Partners V-B, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management V, L.P., general partner of North Bridge Venture Partners V-B, L.P. 2022-04-14 North Bridge Venture Partners VI, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management VI, L.P., general partner of North Bridge Venture Partners VI, L.P. 2022-04-14 North Bridge Venture Management V, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management V, L.P. 2022-04-14 North Bridge Venture Management GP, LLC, /s/ Edward T. Anderson, Manager of NBVM GP 2022-04-14 North Bridge Venture Management VI, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management VI, L.P. 2022-04-14 /s/ Richard A. D'Amore 2022-04-14