X0306 4 2020-05-05 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001401650 NBVM GP, LLC 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001206641 DAMORE RICHARD A 60 WILLIAM STREET, SUITE 350 WELLESLEY 02481 0 0 1 0 0001138402 NORTH BRIDGE VENTURE PARTNERS V A LP 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001138399 NORTH BRIDGE VENTURE PARTNERS V-B LP 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001327539 North Bridge Venture Partners VI L P 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001297397 North Bridge Venture Management V, L.P. 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 0001590898 North Bridge Venture Management VI, L.P. 60 WILLIAM STREET, SUITE 350 WELLESLEY MA 02481 0 0 1 0 Common Stock 2020-05-05 4 C 0 651453 A 651453 I See footnote Common Stock 2020-05-05 4 C 0 319303 A 319303 I See footnote Common Stock 2020-05-05 4 C 0 471929 A 471929 I See footnote Common Stock 2020-05-05 4 X 0 21060 8.63 A 672513 I See footnote Common Stock 2020-05-05 4 S 0 11360 16.00 D 661153 I See footnote Common Stock 2020-05-05 4 X 0 10322 8.63 A 329625 I See footnote Common Stock 2020-05-05 4 S 0 5568 16.00 D 324057 I See footnote Common Stock 2020-05-05 4 X 0 13449 8.63 A 485378 I See footnote Common Stock 2020-05-05 4 S 0 7255 16.00 D 478123 I See footnote Common Stock 2020-05-05 4 P 0 117439 16.00 A 778592 I See Footnote Common Stock 2020-05-05 4 P 0 57561 16.00 A 381618 I See Footnote Common Stock 2020-05-05 4 P 0 75000 16.00 A 553123 I See Footnote Series A-1/A Convertible Preferred Stock 2020-05-05 4 C 0 1157670 D Common Stock 33572 0 I See footnote Series A-1/A Convertible Preferred Stock 2020-05-05 4 C 0 567420 D Common Stock 16455 0 I See footnote Series A-1/A Convertible Preferred Stock 2020-05-05 4 C 0 1725090 D Common Stock 50027 0 I See footnote Series A-1/B Convertible Preferred Stock 2020-05-05 4 C 0 1105754 D Common Stock 32066 0 I See footnote Series A-1/B Convertible Preferred Stock 2020-05-05 4 C 0 541973 D Common Stock 15717 0 I See footnote Series A-1/B Convertible Preferred Stock 2020-05-05 4 C 0 1647727 D Common Stock 47783 0 I See footnote Series A-1/C Convertible Preferred Stock 2020-05-05 4 C 0 3051758 D Common Stock 88500 0 I See footnote Series A-1/C Convertible Preferred Stock 2020-05-05 4 C 0 1495786 D Common Stock 43377 0 I See footnote Series A-1/C Convertible Preferred Stock 2020-05-05 4 C 0 1948948 D Common Stock 56519 0 I See footnote Series A-2 Convertible Preferred Stock 2020-05-05 4 C 0 3270702 D Common Stock 94849 0 I See footnote Series A-2 Convertible Preferred Stock 2020-05-05 4 C 0 1603102 D Common Stock 46489 0 I See footnote Series A-2 Convertible Preferred Stock 2020-05-05 4 C 0 2088772 D Common Stock 60573 0 I See footnote Series A-3 Convertible Preferred Stock 2020-05-05 4 C 0 4587608 D Common Stock 133039 0 I See footnote Series A-3 Convertible Preferred Stock 2020-05-05 4 C 0 2248569 D Common Stock 65208 0 I See footnote Series A-3 Convertible Preferred Stock 2020-05-05 4 C 0 2929790 D Common Stock 84963 0 I See footnote Series A-4 Convertible Preferred Stock 2020-05-05 4 C 0 3745346 D Common Stock 108614 0 I See footnote Series A-4 Convertible Preferred Stock 2020-05-05 4 C 0 1835743 D Common Stock 53236 0 I See footnote Series A-4 Convertible Preferred Stock 2020-05-05 4 C 0 2391895 D Common Stock 69364 0 I See footnote Series B Convertible Preferred Stock 2020-05-05 4 C 0 3124633 D Common Stock 90613 0 I See footnote Series B Convertible Preferred Stock 2020-05-05 4 C 0 1531507 D Common Stock 44413 0 I See footnote Series B Convertible Preferred Stock 2020-05-05 4 C 0 1995489 D Common Stock 57868 0 I See footnote Series C Convertible Preferred Stock 2020-05-05 4 C 0 2420729 D Common Stock 70200 0 I See footnote Series C Convertible Preferred Stock 2020-05-05 4 C 0 1186496 D Common Stock 34408 0 I See footnote Series C Convertible Preferred Stock 2020-05-05 4 C 0 1545953 D Common Stock 44832 0 I See footnote Common Warrants 8.63 2020-05-05 4 X 0 21060 0.00 D 2020-01-17 2030-01-10 Common Stock 21060 0 I See footnote Common Warrants 8.63 2020-05-05 4 X 0 10322 0.00 D 2020-01-17 2030-01-10 Common Stock 10322 0 I See footnote Common Warrants 8.63 2020-05-05 4 X 0 13449 0.00 D 2020-01-17 2030-01-10 Common Stock 13449 0 I See footnote Each share of preferred stock was automatically converted into 0.0289998 shares of common stock upon the closing of the Issuer's initial public offering. The preferred stock had no expiration date. The reportable securities are owned directly by North Bridge Venture Partners V-A, L.P. ("NBVP V-A"). North Bridge Venture Management V, L.P. ("NBVM V") is the sole general partner of NBVP V-A and North Bridge Venture Management GP, LLC ("NBVM GP") is the sole general partner of NBVM V. Each of Edward T. Anderson ("Anderson"), a member of the Issuer's board of directors, and Richard A. D'Amore ("D'Amore") are the managing members of NBVM GP and may be deemed to have shared voting and dispositive power over the shares held by NBVP V-A. Each of NBVM V, NBVM GP, Anderson and D'Amore disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by North Bridge Venture Partners V-B, L.P. ("NBVP V-B"). NBVM V is the sole general partner of NBVP V-B and NBVM GP is the sole general partner of NBVM V. Each of Anderson, a member of the Issuer's board of directors, and D'Amore are the managing members of NBVM GP and may be deemed to have shared voting and dispositive power over the shares held by NBVP V-B. Each of NBVM V, NBVM GP, Anderson and D'Amore disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. The reportable securities are owned directly by North Bridge Venture Partners VI, L.P. ("NBVP VI"). North Bridge Venture Management VI, L.P. ("NBVM VI") is the sole general partner of NBVP VI and NBVM GP is the sole general partner of NBVM VI. Each of Anderson, a member of the Issuer's board of directors, and D'Amore are the managing members of NBVM GP and may be deemed to have shared voting and dispositive power over the shares held by NBVP VI. Each of NBVM VI, NBVM GP, Anderson and D'Amore disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. On May 5, 2020, NBVP V-A exercised a warrant to purchase 21,060 shares of the Issuer's common stock for $16.00 a share, which represents the Issuer's initial public offering price. In connection with the automatic net exercise of the warrant immediately prior to the closing of the Issuer's initial public offering, the Issuer withheld 11,360 of the warrant shares to pay the exercise price and issued the remaining warrant shares to NBVP V-A. The Issuer also paid $12.20 to NBVP V-A in lieu of a fractional share. On May 5, 2020, NBVP V-B exercised a warrant to purchsae 10,322 shares of the Issuer's common stock for $16.00 a share, which represents the Issuer's initial public offering price. In connection with the automatic net exercise of the warrant immediately prior to the closing of the Issuer's initial public offering, the Issuer withheld 5,568 of the warrant shares to pay the exercise price and issued the remaining warrant shares to NBVP V-B. The Issuer also paid $9.14 to NBVP V-B in lieu of a fractional share. On May 5, 2020, NBVP VI exercised a warrant to purchase 13,449 shares of the Issuer's common stock for $16.00 a share, which represents the Issuer's initial public offering price. In connection with the automatic net exercise of the warrant immediately prior to the closing of the Issuer's initial public offering, the Issuer withheld 7,255 of the warrant shares to pay the exercise price and issued the remaining warrant shares to NBVP VI. The Issuer also paid $15.13 to NBVP VI in lieu of a fractional share. North Bridge Venture Partners V-A, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management V, L.P., general partner of North Bridge Venture Partners V-A, L.P. 2020-05-06 North Bridge Venture Partners V-B, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management V, L.P., general partner of North Bridge Venture Partners V-B, L.P. 2020-05-06 North Bridge Venture Partners VI, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management VI, L.P., general partner of North Bridge Venture Partners VI, L.P. 2020-05-06 North Bridge Venture Management V, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management V, L.P. 2020-05-06 North Bridge Venture Management GP, LLC, /s/ Edward T. Anderson, Manager of NBVM GP 2020-05-06 North Bridge Venture Management VI, L.P., /s/ Edward T. Anderson, Manager of NBVM GP, general partner of North Bridge Venture Management VI, L.P. 2020-05-06 /s/ Richard A. D'Amore 2020-05-06