X0306 4 2022-05-02 0 0001401395 Neptune Wellness Solutions Inc. NEPT 0001918825 Cammarata Michael C/O NEPTUNE WELLNESS SOLUTIONS INC. 100- 545 PROMENADE DU CENTROPOLIS LAVAL A8 H7T 0A3 QUEBEC, CANADA 1 1 0 0 President and CEO Common Shares 2022-05-02 4 M 0 77777 A 8712321 D Common Shares 2022-05-02 4 F 0 30605 0.1699 D 8681716 D Common Shares 2022-05-04 4 M 0 3055123 A 11736839 D Common Shares 2022-05-04 4 F 0 1202191 0.1723 D 10534648 D Restricted Share Units 2022-05-02 4 M 0 77777 0.00 D Common Shares 77777 155554 D Restricted Share Units 2022-05-04 4 A 0 3055123 0.00 A Common Shares 3055123 3055123 D Restricted Share Units 2022-05-04 4 M 0 3055123 0.00 D Common Shares 3055123 0 D The restricted share units ("RSUs") vest immediately. Each RSU represents the contingent right to receive one common share upon vesting of the unit. Exempt transaction pursuant to Section 16b-3(e) - payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3. All of the shares reported as disposed of on this Form 4 were relinquished by the Reporting Person and cancelled by the Issuer in exchange for the Issuer's agreement to pay federal and state tax withholding obligations of the Reporting Person resulting from the settlement of vested RSUs. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes. On July 8, 2019, the reporting person was granted 2,800,000 RSUs, subject to vesting and settlement as described in the reporting person's Form 3 filed on April 1, 2022. The RSUs vest immediately. /s/ Christopher Piazza for Michael Cammarata as Attorney-in-Fact 2022-05-04