144 0001401385 XXXXXXXX LIVE 0001937993 CADRENAL THERAPEUTICS, INC. 001-41596 822 A1A North, Suite 306 Ponte Vedra FL 32082 9043000701 MATTHEW SZOT Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

100 1403.00 2046854 09/29/2025 NASDAQ Common 05/17/2022 Founders Shares Issuer N 100 05/17/2022 N/A N 10b5-1 Sales for MATTHEW SZOT

822 A1A North, Suite 306 Ponte Vedra FL 32082

Common 09/25/2025 10900 153182.06 10b5-1 Sales for MATTHEW SZOT

822 A1A North, Suite 306 Ponte Vedra FL 32082

Common 09/24/2025 1500 20992.95 10b5-1 Sales for MATTHEW SZOT

822 A1A North, Suite 306 Ponte Vedra FL 32082

Common 08/28/2025 400 5600.00 10b5-1 Sales for MATTHEW SZOT

822 A1A North, Suite 306 Ponte Vedra FL 32082

Common 08/27/2025 1600 22392.00 09/29/2025 05/09/2025 /s/ Matthew Szot