X0508 4 2025-06-01 0001401040 DiaMedica Therapeutics Inc. DMAC 0001759822 Giuffre Randall Michael 301 CARLSON PARKWAY, SUITE 210 MINNEAPOLIS MN 55305 1 0 Voting Common Shares, no par value per share 392412 D Voting Common Shares, no par value per share 25573 I See footnote Voting Common Shares, no par value per share 21070 I By Spouse Stock Option (right to buy) 4.11 2025-06-01 4 A 0 32162 0 A 2035-05-31 Common Shares 32162 32162 D Includes 4,146 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan, 95,016 shares issuable upon settlement of deferred stock units granted under the DiaMedica Therapeutics Inc. 2019 Omnibus Incentive Plan, as amended from time to time, 164,890 voting common shares held by Michael Giuffre and his wife jointly and 128,360 voting common shares held by Michael Giuffre individually. These voting common shares are held by 424822 Albert Ltd, of which Michael Giuffre has sole voting and dispositive power. Vests in four nearly equal quarterly installments over one year. /s/ Scott Kellen, attorney-in-fact 2025-06-03