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Note 12 - Share-based Compensation (Tables)
3 Months Ended
Mar. 31, 2022
Notes Tables  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
  

Three Months Ended March 31,

 
  

2022

  

2021

 

Research and development

 $91  $131 

General and administrative

  217   380 

Total share-based compensation

 $308  $511 
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
  

Shares

Underlying

Options

Outstanding

  

Weighted

Average Exercise

Price Per Share

  

Aggregate

Intrinsic Value

 

Balances at December 31, 2021

  1,896,600  $5.25  $169 

Granted

  325,000   3.38     

Exercised

          

Expired/cancelled

  (10,000)  27.18     

Forfeited

  (52,187)  4.94     

Balances at March 31, 2022

  2,159,413  $4.88  $ 
Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
    

Outstanding, Vested and Expected to Vest

  

Options Vested and Exercisable

 

Per Share Exercise Price

 

Shares

  

Weighted Average Remaining

Contractual Life

(Years)

  

Weighted Average

Exercise Price

  

Options

Exercisable

  

Weighted Average Remaining

Contractual Life

(Years)

 

$2.00

-$2.99  285,500   7.3  $2.70   120,500   3.7 

$3.00

-$3.99  330,508   8.8   3.82   68,647   6.7 

$4.00

-$4.99  928,150   7.2   4.51   840,151   7.1 

$5.00

-$9.99  571,088   7.9   6.47   272,963   6.4 

$10.00

-$27.06  44,167   4.2   14.32   34,167   2.8 
     2,159,413   7.6  $4.88   1,336,428   6.5