X0306 4 2022-06-01 0 0001401040 DiaMedica Therapeutics Inc. DMAC 0001760016 Pilnik Richard D. 2 CARLSON PARKWAY SUITE 260 MINNEAPOLIS MN 55447 1 0 0 0 Voting Common Shares, no par value per share 119327 D Stock Option (right to buy) 2.45 2022-06-01 4 A 0 18510 0 A 2032-05-31 Common Shares 18510 18510 D Includes 7,588 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan and 43,649 shares issuable upon settlement of deferred stock units granted under the DiaMedica Therapeutics Inc. 2019 Omnibus Incentive Plan. Vests in four nearly equal quarterly installments over one year. /s/ Amy Culbert, attorney-in-fact 2022-06-02