X0306 4 2022-01-03 0 0001401040 DiaMedica Therapeutics Inc. DMAC 0001759822 Giuffre Randall Michael TWO CARLSON PARKWAY SUITE 260 MINNEAPOLIS MN 55447 1 0 0 0 Voting Common Shares, no par value per share 2022-01-03 4 A 0 15026 3.58 A 110225 D Voting Common Shares, no par value per share 25573 I See footnote Voting Common Shares, no par value per share 21070 I By Spouse Voting Common Shares, no par value per share 54186 I By Children These shares are issuable upon settlement of deferred stock units granted under the DiaMedica Therapeutics Inc. 2019 Omnibus Incentive Plan in lieu of cash retainer fees in the aggregate amount of $53,750. Amount reflects the cancellation of 422 shares underlying deferred share units granted in lieu of Board committee retainers due to a change in Board committee memberships. Includes 4,146 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan, 29,829 shares issuable upon settlement of deferred stock units granted under the DiaMedica Therapeutics Inc. 2019 Omnibus Incentive Plan, 14,890 voting common shares held by Michael Giuffre and his wife jointly and 61,360 voting common shares held by Michael Giuffre individually. These voting common shares are held by 424822 Albert Ltd, of which Michael Giuffre has sole voting and dispositive power. /s/ Amy Culbert, attorney-in-fact 2022-01-03