X0306 4 2021-08-16 0 0001401040 DiaMedica Therapeutics Inc. DMAC 0001760123 Pauls Dietrich John TWO CARLSON PARKWAY, SUITE 260 MINNEAPOLIS MN 55447 1 1 0 0 President and CEO Voting Common Shares, no par value per share 2021-08-16 4 P 0 5000 3.14 A 35804 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.12 to $3.15, inclusive. The reporting person undertakes to provide to DiaMedica Therapeutics Inc., any security holder of DiaMedica Therapeutics Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4. Includes 1,749 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan. /s/ Amy Culbert, attorney-in-fact 2021-08-16