X0306 4 2020-11-20 0 0001401040 DiaMedica Therapeutics Inc. DMAC 0001759822 Giuffre Randall Michael 2 CARLSON PARKWAY SUITE 260 MINNEAPOLIS MN 55447 1 0 0 0 Voting Common Shares, no par value per share 2020-11-20 4 P 0 15000 4.2608 A 108588 D Voting Common Shares, no par value per share 5165 I See footnote Voting Common Shares, no par value per share 21070 I By Spouse Voting Common Shares, no par value per share 54186 I By Children The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.249 to $4.283, inclusive. The reporting person undertakes to provide to DiaMedica Therapeutics Inc., any security holder of DiaMedica Therapeutics Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4. Includes 4,146 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan, 7,784 shares issuable upon settlement of deferred stock units granted under the DiaMedica Therapeutics Inc. 2019 Omnibus Incentive Plan, 36,498 voting common shares held by Michael Giuffre and his wife jointly and 60,160 voting common shares held by Michael Giuffre individually. These voting common shares are held by 424822 Albert Ltd, of which Michael Giuffre has sole voting and dispositive power. /s/ Amy Culbert, attorney-in-fact 2020-11-23