X0306 4 2018-12-11 0 0001401040 DiaMedica Therapeutics Inc. DMAC 0001759822 Giuffre Randall Michael 2 CARLSON PARKWAY SUITE 260 MINNEAPOLIS MN 55447 1 0 0 0 Voting Common Shares, no par value per share 2018-12-11 4 P 0 11250 4 A 85804 D Voting Common Shares, no par value per share 5165 I See footnote Voting Common Shares, no par value per share 21070 I By Spouse Voting Common Shares, no par value per share 54186 I By Children Includes 4,146 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan, 36,498 voting common shares held by Michael Giuffre and his wife jointly and 45,160 voting common shares held by Michael Giuffre individually. These voting common shares are held by 424822 Albert Ltd, of which Michael Giuffre has sole voting and dispositive power. /s/ Amy Culbert, attorney-in-fact 2018-12-11