<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>SCHEDULE 13G/A</submissionType>
<previousAccessionNumber>0000945621-25-000820</previousAccessionNumber>
<filerInfo>
<filer>
<filerCredentials>
<cik>0000898382</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<amendmentNo>2</amendmentNo>
<securitiesClassTitle>Voting Common Shares, no par value</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>12/31/2025</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0001401040</issuerCik>
<issuerName>DiaMedica Therapeutics Inc.</issuerName>
<issuerCusip>25253X207</issuerCusip>
<issuerPrincipalExecutiveOfficeAddress>
<com:street1>301 Carlson Parkway, Suite 210</com:street1>
<com:city>Minneapolis</com:city>
<com:stateOrCountry>MN</com:stateOrCountry>
<com:zipCode>55305</com:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
</coverPageHeader>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Cooperman Leon G.</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>3450000</soleVotingPower>
<sharedVotingPower>0</sharedVotingPower>
<soleDispositivePower>3450000</soleDispositivePower>
<sharedDispositivePower>0</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3450000</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>6.6</classPercent>
<typeOfReportingPerson>IN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<items>
<item1>
<issuerName>DiaMedica Therapeutics Inc.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>301 Carlson Parkway, Suite 210, Minneapolis, Minnesota, 55305</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>This statement is filed on behalf of Leon G. Cooperman ("Mr. Cooperman"). Mr. Cooperman is engaged in, among other activities, investing for his own account.&#13;
&#13;
Mr. Cooperman is married to an individual named Toby Cooperman. Mr. Cooperman is one of the trustees of The Leon and Toby Cooperman Foundation (the "Foundation"), a charitable trust dated December 16, 1981.</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>Mr. Cooperman's principal business office address is St. Andrews Country Club, 7118 Melrose Castle Lane, Boca Raton, FL 33496.</principalBusinessOfficeOrResidenceAddress>
<citizenship>Mr. Cooperman is a United States citizen.</citizenship>
</item2>
<item3>
<notApplicableFlag>Y</notApplicableFlag>
</item3>
<item4>
<amountBeneficiallyOwned>The information required by this item with respect to the Reporting Person is set forth in Rows 5 through 9 and 11 of the cover page to this Schedule 13G. Mr. Cooperman may be deemed the beneficial owner of 3,450,000 Common Shares, which is comprised of: (i) 2,450,000 Common Shares held directly by Mr. Cooperman and (ii) 1,000,000 Common Shares held directly by the Foundation, which collectively constitute approximately 6.6% of the total number of Common Shares outstanding, calculated based on 52,077,439 Common Shares outstanding as of November 10, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2025.</amountBeneficiallyOwned>
<classPercent>6.6%</classPercent>
<numberOfSharesPersonHas>
<solePowerOrDirectToVote>3,450,000</solePowerOrDirectToVote>
<sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
<solePowerOrDirectToDispose>3,450,000</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
</numberOfSharesPersonHas>
</item4>
<item5>
<notApplicableFlag>Y</notApplicableFlag>
</item5>
<item6>
<notApplicableFlag>Y</notApplicableFlag>
</item6>
<item7>
<notApplicableFlag>Y</notApplicableFlag>
</item7>
<item8>
<notApplicableFlag>Y</notApplicableFlag>
</item8>
<item9>
<notApplicableFlag>Y</notApplicableFlag>
</item9>
<item10>
<notApplicableFlag>N</notApplicableFlag>
<certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
</item10>
</items>
<signatureInformation>
<reportingPersonName>Cooperman Leon G.</reportingPersonName>
<signatureDetails>
<signature>/s/ Edward Levy</signature>
<title>Edward Levy, Attorney-in-Fact</title>
<date>02/17/2026</date>
</signatureDetails>
</signatureInformation>
<signatureComments>Duly authorized under POA effective as of August 10, 2016 and filed on August 12, 2016.</signatureComments>
</formData>
</edgarSubmission>
