X0206 3 2014-02-03 0 0001400482 ACUCELA INC. M?????? 0001408498 Lowrance David L C/O ACUCELA INC. 1301 SECOND AVE., SUITE 1900 SEATTLE WA 98101 0 1 0 0 CFO, Secretary, Treasurer Common Stock 0 D Stock Option (right to buy) 4.52 2021-05-17 Common Stock 67500 D Stock Option (right to buy) 9.30 2022-05-24 Common Stock 67900 D The issuer's common stock will trade on the Tokyo Stock Exchange under the symbol referenced in the issuer's registration statement on Form S-1 (File No. 333-1929000). The option vests and is exercisable at the rate of 1/5th of the total shares on April 23, 2012 and then an additional 1/5th yearly thereafter, with 100% vested and exercisable on April 23, 2016, subject to the reporting person's provision of service to the issuer on each vesting date. The option vests and is exercisable at the rate of 1/5th of the total shares on April 23, 2013 and then an additional 1/5th yearly thereafter, with 100% vested and exercisable on April 23, 2017, subject to the reporting person's provision of service to the issuer on each vesting date. /s/ Hien DeYoung as attorney-in-fact for David L. Lowrance 2014-02-03