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DEPRECIATION, SHARE-BASED PAYMENTS, EMPLOYEE AND OTHER EXPENSES (Details) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Expense by nature      
Selling expenses $ 2,996,292 $ 2,196,803 $ 1,645,985
General and administrative expenses 14,655,957 14,081,153 10,013,732
Product development and clinical trials expenses 15,449,001 20,401,595 20,020,959
TOTAL EXPENSES 33,101,250 36,679,551 31,680,676
Depreciation per Statements of Cash Flows 670,977 768,101 641,621
Share-based payments per Statements of Cash Flows 5,285,813 4,905,812 3,189,808
Cash-based employee expenses 9,553,852 12,006,724 10,875,930
Depreciation      
Expense by nature      
General and administrative expenses 307,015 280,949 182,202
Product development and clinical trials expenses 363,962 487,152 459,419
Share-based payments      
Expense by nature      
Selling expenses 685,273 320,886 188,930
General and administrative expenses 3,801,729 2,820,369 1,748,660
Product development and clinical trials expenses 798,811 1,764,557 1,252,218
Cash-based employee expenses      
Expense by nature      
Selling expenses 921,772 891,784 526,769
General and administrative expenses 3,218,867 3,149,313 2,725,814
Product development and clinical trials expenses 5,413,213 7,965,627 7,623,347
Employee termination expenses      
Expense by nature      
General and administrative expenses 210,893   26,050
Write down of fixed assets for obsolescence      
Expense by nature      
General and administrative expenses 593,622    
Litigation expenses      
Expense by nature      
General and administrative expenses 921,564 284,729 81,171
Accretion on collaboration, license and settlement agreements provision      
Expense by nature      
General and administrative expenses 63,400 308,938 693,047
Legal expenses and underwriters fees from financing activities      
Expense by nature      
General and administrative expenses 1,546,811 3,617,485 1,089,245
Other expenses      
Expense by nature      
Selling expenses 1,389,247 984,133 930,286
General and administrative expenses 3,992,056 3,619,370 3,467,543
Product development and clinical trials expenses $ 8,873,015 $ 10,184,259 $ 10,685,975