ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Tables)

12 Months Ended

Dec. 31, 2021

ACCOUNTS PAYABLE AND ACCRUED LIABILITIES

Schedule of accounts payable and accrued liabilities

	December 31,		December 31,		December 31,
	2021		2020		2019
Current accounts payable and accrued liabilities
Trade payables	$	1,434,357	$	3,705,626	$	3,993,203
Accrued liabilities		2,113,594		1,421,433		2,163,886
Accrued vacation		293,553		335,681		211,168
Accrued severance provision		—		—		13,887
Other accounts payable		278,041		535,124		320,306
Share appreciation rights liability		509,618		59,036		—
Collaboration, license, and settlement agreements provision		—		1,186,600		1,092,006
Total current accounts payable and accrued liabilities	$	4,629,163	$	7,243,500	$	7,794,456
Non-current accrued liabilities
Non-current collaboration, license and settlement agreements provision		—		—		1,186,601
	$	—	$	—	$	1,186,601
Total accounts payable and accrued liabilities	$	4,629,163	$	7,243,500	$	8,981,057