December 31,

December 31,

2021

2020

2019

Current accounts payable and accrued liabilities

Trade payables

$

1,434,357

$

3,705,626

$

3,993,203

Accrued liabilities

2,113,594

1,421,433

2,163,886

Accrued vacation

293,553

335,681

211,168

Accrued severance provision

—

13,887

Other accounts payable

278,041

535,124

320,306

Share appreciation rights liability

509,618

59,036

—

Collaboration, license, and settlement agreements provision

—

1,186,600

1,092,006

Total current accounts payable and accrued liabilities

$

4,629,163

$

7,243,500

$

7,794,456

Non-current accrued liabilities

Non-current collaboration, license and settlement agreements provision

—

1,186,601

$

—

$

—

$

1,186,601

Total accounts payable and accrued liabilities

$

4,629,163

$

7,243,500

$

8,981,057