DEPRECIATION, SHARE-BASED PAYMENTS, EMPLOYEE AND OTHER EXPENSES

12 Months Ended

Dec. 31, 2018

DEPRECIATION, SHARE-BASED PAYMENTS, EMPLOYEE AND OTHER EXPENSES

DEPRECIATION, SHARE-BASED PAYMENTS, EMPLOYEE AND OTHER EXPENSES

20.    DEPRECIATION, SHARE-BASED PAYMENTS, EMPLOYEE AND OTHER EXPENSES

	For the years ended December 31,
	2018		2017		2016
EXPENSES
Selling expenses
Share-based payments	$	170,416	$	98,379	$	138,334
Cash-based employee expenses		352,837		202,261		109,150
Other expenses		829,912		585,586		449,154
	$	1,353,165	$	886,226	$	696,638
General and administrative expenses
Depreciation		60,206		93,196		119,977
Share-based payments		2,147,832		1,080,627		510,508
Cash-based employee expenses		2,498,005		2,792,897		2,713,110
Litigation expenses		540,125		2,410,350		13,170,138
Employee termination expenses		761,354		—		—
Collaboration and settlement expenses (see Note 24)		2,379,790		—		—
Settlement provision (see Note 24)		2,749,968		—		—
Expenses related to the 2017 Financings		—		5,447,182		—
Other expenses		5,301,656		3,860,531		2,669,054
	$	16,438,936	$	15,684,783	$	19,182,787
Product development and clinical trials expenses
Depreciation		323,920		382,234		426,144
Share-based payments		974,629		1,305,535		1,160,269
Cash-based employee expenses		6,691,371		7,609,387		10,195,949
Other expenses		8,070,937		8,191,936		7,582,141
		16,060,857		17,489,092		19,364,503
TOTAL EXPENSES	$	33,852,958	$	34,060,101	$	39,243,928
Depreciation per Statements of Cash Flows	$	384,126	$	534,545	$	755,734
Share-based payments per Statements of Cash Flows	$	3,292,877	$	2,484,543	$	1,810,111
Cash-based employee expenses (see Note 19)	$	9,542,213	$	10,562,480	$	11,759,114