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Share-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Summary of Share-Based Compensation Expense
The Company recognized share-based compensation in its Consolidated Statements of Operations during the periods presented as follows:

Expense classification:Year Ended December 31, 2022Year Ended December 31, 2021
Manufacture and supply$203 $313 
Research and development672 881 
Selling, general and administrative3,506 5,625 
Total share-based compensation expenses$4,381 $6,819 
Share-based compensation from:
Restricted Stock Units127 81 
Stock Options4,244 6,714 
Employee Stock Purchase Plan10 24 
Total share-based compensation expenses$4,381 $6,819 
Summary of Restricted Stock Units The following table summarizes the Company’s awards of restricted stock units for the years during 2021 and 2022:
 Number
of Units
Weighted Average
Grant Date Fair
Value Per Share
 (In thousands) 
Unvested, December 31, 202014$11.38 
Granted— 
Forfeited(2)13.00 
Vested(12)11.14 
Unvested, December 31, 2021
Granted1922.37 
Forfeited(20)2.21 
Vested(10)2.55 
Unvested, December 31, 2022162$2.38 
Summary of Stock Option Activity
The following table summarizes the Company’s stock option activity for the years during 2021 and 2022:

(in 000s, except share price data)Number
of Options
Weighted
Average
Exercise Price
Weighted
Average
Remaining
Contractual
Term in Years
Aggregate
Intrinsic Value
Outstanding at December 31, 20203,259 $8.14 8.42$2,978 
Granted1,212 $4.73 
Forfeited and Expired(264)$7.52 
Exercised(61)
Outstanding at December 31, 20214,146 $7.28 7.88$1,423 
Granted2,015 1.83 
Forfeited and Expired(133)$7.81 
Exercised— $— 
Outstanding at December 31, 20226,028 $5.48 7.50$38 
Vested and expected to vest at December 31, 20225,877 $5.57 7.46$36 
Exercisable at December 31, 20223,652 $7.42 6.57$— 
Summary of Stock Option Valuation Assumptions The fair values of stock options granted were estimated using the Black-Scholes model based on the following assumptions:
 Year Ended December 31,
 20222021
Expected dividend yield0%0%
Expected volatility100%100%
Expected term (years)5.50-6.135.50-6.00
Risk-free interest rate2.0%—%4.3%0.5%—%1.5%
Exercise prices$0.71-$2.55$3.76-$5.30