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Share-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Share-based Compensation Expense
The Company recognized share-based compensation in its Condensed Consolidated Statements of Operations and Comprehensive Loss during 2022 and 2021 as follows:

 Three Months Ended
June 30,		Six Months Ended
June 30,
 2022202120222021
Manufacture and supply$45 $71 $93 $153 
Research and development162 208 331 440 
Selling, general and administrative2,014 1,442 2,710 2,635 
Total share-based compensation expenses$2,221 $1,721 $3,134 $3,228 
Share-based compensation from:
Restricted stock units$39 $43 $39 $81 
Stock options2,180 1,667 3,093 3,136 
Employee stock purchase plan2 11 2 11 
Total share-based compensation expenses$2,221 $1,721 $3,134 $3,228 
Restricted Stock Units Awards The following tables provide information about the Company’s restricted stock unit and stock option activity during the six-month period ended June 30, 2022:
Restricted Stock Unit Awards (RSUs):Number of
Units		Weighted
Average
Grant Date Fair
Value
 (in thousands) 
Unvested as of December 31, 2021— $— 
Granted192 $2.38 
Vested— $— 
Forfeited(22)$2.24 
Unvested as of June 30, 2022170 $2.39 
Vested and expected to vest as of June 30, 2022154 $2.39 
Stock Option Activity
Stock Option Awards:Number of
Options		Weighted Average
Exercise Price
 (in thousands)
Outstanding as of December 31, 20214,146 $7.28 
Granted1,250 $2.37 
Exercised, Forfeited, Expired(112)$5.96 
Outstanding as of June 30, 20225,284 $6.14 
Vested and expected to vest as of June 30, 20225,155 $6.22 
Exercisable as of June 30, 20223,461 $7.65 
Valuation Assumptions for Determination of Fair Value of Options
The fair values of stock options granted during the six months ended June 30, 2022 were estimated using the Black-Scholes pricing model based on the following assumptions:

Expected dividend yield—%
Expected volatility
100%
Expected term (years)5.5-6.1
Risk-free interest rate2.0 %-3.2%