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Share-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2022
Share-based Payment Arrangement [Abstract]  
Share-based Compensation Expense The Company recognized share-based compensation in its Condensed Consolidated Statements of Operations and Comprehensive Loss during 2022 and 2021 as follows:
 Three Months Ended
March 31,
 20222021
Manufacture and supply$48 $82 
Research and development169 232 
Selling, general and administrative696 1,193 
Total share-based compensation expenses$913 $1,507 
Share-based compensation from:
Restricted stock units$— $38 
Stock options913 1,469 
Employee stock purchase plan— — 
Total share-based compensation expenses$913 $1,507 
Restricted Stock Units Awards
The following tables provide information about the Company’s restricted stock unit and stock option activity during the three-month period ended March 31, 2022:
Restricted Stock Unit Awards (RSUs):Number of
Units		Weighted
Average
Grant Date Fair
Value
 (in thousands) 
Unvested as of December 31, 2021— $— 
Granted166 $2.55 
Vested— $— 
Forfeited— $— 
Unvested as of March 31, 2022166 $— 
Grant date fair value of shares vested during the period$— 
Unrecognized compensation costs as of March 31, 2022$377 
Stock Option Activity
Stock Option Awards:Number of
Options		Weighted Average
Exercise Price
 (in thousands)
Outstanding as of December 31, 20214,146 $7.28 
Granted1,125 $2.55 
Exercised, Forfeited, Expired(11)$4.98 
Outstanding as of March 31, 20225,260 $6.27 
Vested and expected to vest as of March 31, 20225,047 $6.39 
Exercisable as of March 31, 20222,496 $9.25 
Valuation Assumptions for Determination of Fair Value of Options
The fair values of stock options granted during the three months ended March 31, 2022 were estimated using the Black-Scholes pricing model based on the following assumptions:

Expected dividend yield— %
Expected volatility
100%
Expected term (years)6.1
Risk-free interest rate2.0 %