Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Income Statement [Abstract]
Revenues	$ 50,832	$ 45,849
Costs and expenses:
Manufacture and supply	14,989	12,964
Research and development	17,047	19,886
Selling, general and administrative	53,475	55,892
Total costs and expenses	85,511	88,742
Loss from operations	(34,679)	(42,893)
Other income (expenses):
Interest expense	(10,049)	(11,064)
Interest expense related to the sale of future revenue	(12,412)	(1,958)
Interest income and other income, net	423	132
Loss on the extinguishment of debt	(13,822)	0
Net loss before income taxes	(70,539)	(55,783)
Income taxes	0	0
Net loss	(70,539)	(55,783)
Comprehensive loss	$ (70,539)	$ (55,783)
Net loss per share - basic (in usd per share)	$ (1.85)	$ (1.66)
Net loss per share - diluted (in usd per share)	$ (1.85)	$ (1.66)
Weighted-average number of common shares outstanding - basic (in shares)	38,077,660	33,651,127
Weighted-average number of common shares outstanding - diluted (in shares)	38,077,660	33,651,127