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Share-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Summary of Share-Based Compensation Expense
The Company recognized share-based compensation in its Consolidated Statements of Operations during the periods presented as follows:

Expense classification:Year Ended December 31, 2021Year Ended December 31, 2020
Manufacture and supply$313 $275 
Research and development881 729 
Selling, general and administrative5,625 5,577 
Total share-based compensation expenses$6,819 $6,581 
Share-based compensation from:
Restricted Stock Units81 806 
Stock Options6,714 5,751 
Employee Stock Purchase Plan24 24 
Total share-based compensation expenses$6,819 $6,581 
Summary of Restricted Stock Units
The following table summarizes the Company’s awards of restricted stock units for the years during 2020 and 2021:

 Number
of Units
Weighted Average
Grant Date Fair
Value Per Share
 (In thousands) 
Unvested, December 31, 201974$14.64 
Granted47.54 
Forfeited— 
Vested(64)14.88 
Unvested, December 31, 202014$11.38 
Granted— 
Forfeited(2)13.00 
Vested(12)11.14 
Unvested, December 31, 2021
Summary of Stock Option Activity
The following table summarizes the Company’s stock option activity for the years during 2020 and 2021:

(in 000s, except share price data)Number
of Options
Weighted
Average
Exercise Price
Weighted
Average
Remaining
Contractual
Term in Years
Aggregate
Intrinsic Value
Outstanding at December 31, 20192,231 $10.42 8.94$689 
Granted1,168 $3.32 
Forfeited(140)$4.36 
Exercised— 
Outstanding at December 31, 20203,259 $8.14 8.42$2,978 
Granted1,212 4.73 
Forfeited and Expired(264)$7.52 
Exercised(61)$1.58 
Outstanding at December 31, 20214,146 $7.28 7.88$1,423 
Vested and expected to vest at December 31, 20214,026 $7.36 7.85$1,377 
Exercisable at December 31, 20211,855 $10.44 6.98$365 
Summary of Stock Option Valuation Assumptions
The fair values of stock options granted were estimated using the Black-Scholes model based on the following assumptions:

 Year Ended December 31,
 20212020
Expected dividend yield0%0%
Expected volatility100%100%
Expected term (years)5.50-6.005.50-6.10
Risk-free interest rate0.50%-1.46%0.33%-1.69%
Exercise prices$3.76-$5.30$1.54-$7.86