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Share-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2021
Share-based Payment Arrangement [Abstract]  
Share-based Compensation Expense
The Company recognized share-based compensation in its Condensed Consolidated Statements of Operations and Comprehensive Loss during 2021 and 2020 as follows:

 Three Months Ended
September 30,		Nine Months Ended
September 30,
 2021202020212020
Manufacture and supply$88 $72 $241 $135 
Research and development230 183 670 365 
Selling, general and administrative1,582 1,510 4,217 3,125 
Total share-based compensation expenses$1,900 $1,765 $5,128 $3,625 
Share-based compensation from:
Restricted stock units$— $309 $81 $773 
Stock options1,900 1,445 5,036 2,841 
Employee stock purchase plan— 11 11 11 
Total share-based compensation expenses$1,900 $1,765 $5,128 $3,625 
Restricted Stock Units Awards
The following tables provide information about the Company’s restricted stock unit and stock option activity during the nine-month period ended September 30, 2021:
Restricted Stock Unit Awards (RSUs):Number of
Units		Weighted
Average
Grant Date Fair
Value
 (in thousands) 
Unvested as of December 31, 202014 $11.38 
Granted— — 
Vested(12)$11.14 
Forfeited(2)$13.00 
Unvested as of September 30, 2021— $— 
Grant date fair value of shares vested during the period$134 
Unrecognized compensation costs as of September 30, 2021$— 
Stock Option Activity
Stock Option Awards:Number of
Options		Weighted Average
Exercise Price
 (in thousands)
Outstanding as of December 31, 20203,259 $8.14 
Granted1,211 $4.73 
Exercised, Forfeited, Expired(128)$5.11 
Outstanding as of September 30, 20214,342 $7.28 
Vested and expected to vest as of September 30, 20214,194 $7.37 
Exercisable as of September 30, 20212,018 $10.18 
Valuation Assumptions for Determination of Fair Value of Options The fair values of stock options granted during the nine months ended September 30, 2021 were estimated using the Black-Scholes pricing model based on the following assumptions:
Expected dividend yield— %
Expected volatility
95% - 100%
Expected term (years)6.1
Risk-free interest rate1.0 %