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Share-Based Compensation
 9 Months Ended
Sep. 30, 2021
Share-based Payment Arrangement [Abstract]  
Share-Based Compensation Share-Based Compensation
The Company recognized share-based compensation in its Condensed Consolidated Statements of Operations and Comprehensive Loss during 2021 and 2020 as follows:

 Three Months Ended
September 30,		Nine Months Ended
September 30,
 2021202020212020
Manufacture and supply$88 $72 $241 $135 
Research and development230 183 670 365 
Selling, general and administrative1,582 1,510 4,217 3,125 
Total share-based compensation expenses$1,900 $1,765 $5,128 $3,625 
Share-based compensation from:
Restricted stock units$— $309 $81 $773 
Stock options1,900 1,445 5,036 2,841 
Employee stock purchase plan— 11 11 11 
Total share-based compensation expenses$1,900 $1,765 $5,128 $3,625 

Share-Based Compensation Equity Awards

The following tables provide information about the Company’s restricted stock unit and stock option activity during the nine-month period ended September 30, 2021:
Restricted Stock Unit Awards (RSUs):Number of
Units		Weighted
Average
Grant Date Fair
Value
 (in thousands) 
Unvested as of December 31, 202014 $11.38 
Granted— — 
Vested(12)$11.14 
Forfeited(2)$13.00 
Unvested as of September 30, 2021— $— 
Grant date fair value of shares vested during the period$134 
Unrecognized compensation costs as of September 30, 2021$— 
Stock Option Awards:Number of
Options		Weighted Average
Exercise Price
 (in thousands)
Outstanding as of December 31, 20203,259 $8.14 
Granted1,211 $4.73 
Exercised, Forfeited, Expired(128)$5.11 
Outstanding as of September 30, 20214,342 $7.28 
Vested and expected to vest as of September 30, 20214,194 $7.37 
Exercisable as of September 30, 20212,018 $10.18 

The fair values of stock options granted during the nine months ended September 30, 2021 were estimated using the Black-Scholes pricing model based on the following assumptions:
Expected dividend yield— %
Expected volatility
95% - 100%
Expected term (years)6.1
Risk-free interest rate1.0 %

The weighted average grant date fair value of stock options granted during the nine months ended September 30, 2021 was $3.61. During the nine-month period ended September 30, 2021, stock options were granted with an exercise price ranging from $3.76 to $5.30 and accordingly, given the Company’s share price of $4.36 at September 30, 2021, certain shares granted during this period provided intrinsic value at that date totaling $159.

As of September 30, 2021, $4,691 of unrecognized compensation expense related to non-vested stock options is expected to be recognized over a weighted average period of 1.8 years from the date of grant.

The Company did not grant restricted stock units during the nine months ended September 30, 2021. There were no unvested restricted stock units and no unrecognized compensation expense related to restricted stock units at September 30, 2021.

Employee Stock Purchase Plan

The Company's Employee Stock Purchase Plan ("ESPP"), as amended and restated effective as of January 1, 2019, features two six-month offering periods per year, running from January 1 to June 30 and July 1 to December 31. Under the ESPP, employees may elect to purchase the Company’s common stock at the lower of 85% of the fair value of shares on either the first or last day of the offering period. During the nine-month periods ended September 30, 2021 and 2020, respectively, 19,270 and 14,961 shares were purchased and issued through the ESPP at total discounts of $11 and $11.