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Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2020
Share-Based Compensation [Abstract]  
Share-based Compensation Expense
The Company recognized share-based compensation in its Consolidated Statements of Operations during the periods presented as follows:

Expense classification:
 
Year Ended
December 31,
2020
  
Year Ended
December 31,
2019
 
Manufacture and supply
 
$
275
  
$
231
 
Research and development
  
729
   
720
 
Selling, general and administrative
  
5,577
   
6,120
 
Total share-based compensation expenses
 
$
6,581
  
$
7,071
 
Share-based compensation from:
        
Restricted Stock Units (A)
  
806
   
1,863
 
Stock Options (B)
  
5,751
   
5,173
 
Employee Stock Purchase Plan (C)
  
24
   
35
 
Total share-based compensation expenses
 
$
6,581
  
$
7,071
 
Restricted Stock Unit Awards
The following table summarizes the Company’s awards of restricted stock units for the year ended December 31, 2019 and 2020:

  
Number
of Units
  
Weighted Average
Grant Date Fair
Value Per Share
 
  
(In thousands)
    
Unvested, December 31, 2018
  
205
  
$
14.77
 
Granted
  
—
   
—
 
Forfeited
  
(6
)
  
—
 
Vested
  
(125
)
  
14.94
 
Unvested, December 31, 2019
  
74
  
$
14.64
 
Granted
  
4
   
7.54
 
Forfeited
  
—
   
—
 
Vested
  
(64
)
  
14.88
 
Unvested, December 31, 2020
  
14
  
$
11.38
 
Stock Option Activity
The following table summarizes the Company’s stock option activity for the period from December 31, 2018 through December 31, 2020:

(in 000s, except share price data)
 
Number
of Options
  
Weighted
Average
Exercise Price
  
Weighted
Average
Remaining
Contractual
Term in Years
  
Aggregate
Intrinsic Value
 
Outstanding at December 31, 2018
  
1,033
  
$
14.72
   
9.55
  
$
—
 
Granted
  
1,258
  
$
6.66
         
Forfeited
  
(60
)
 
$
5.78
         
Exercised
  
—
             
Outstanding at December 31, 2019
  
2,231
  
$
10.42
   
8.94
  
$
689
 
Granted
  
1,168
   
3.32
         
Forfeited
  
(140
)
 
$
4.36
         
Exercised
  
—
          
$
—
 
Outstanding at December 31, 2020
  
3,259
  
$
8.14
   
8.42
  
$
2,978
 
Vested and expected to vest at December 31, 2020
  
3,035
  
$
8.14
   
8.42
  
$
2,758
 
Exercisable at December 31, 2020
  
1,235
  
$
11.26
   
7.89
  
$
403
 
Valuation Assumptions for Determination of Fair Value of Options
The weighted average grant date fair value of stock options granted during 2020 and 2019 was $2.61 and $4.95, respectively. The fair values of stock options granted were estimated using the Black-Scholes model based on the following assumptions:

     Year Ended December 31, 
 
  2020
 
2019
 
Expected dividend yield
   0% 

  0% 

Expected volatility
  
100%
   
85% — 106%

Expected term (years)
  
5.50 — 6.10
   
5.50 — 6.10
 
Risk-free interest rate
  
0.33% — 1.69%
   
1.5% — 2.6%

Exercise prices $
 1.54 — 7.86   $
 3.36 — 8.05