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Share-Based Compensation (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses $ 1,810 $ 27,305 $ 3,330 $ 27,305
Additional Disclosures [Abstract]        
Share price (in dollars per share) $ 15.00   $ 15.00  
Manufacturing and Supply [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses $ 72 345 $ 116 345
Research and Development [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses 140 2,186 348 2,186
Selling, General and Administrative [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses 1,598 24,774 2,866 24,774
Non-voting Common Shares [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses 0 27,298 0 27,298
Restricted Stock Units [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses $ 467 0 $ 930 0
Number of Units [Roll Forward]        
Unvested, at beginning of period (in shares)     205,000  
Granted (in shares)     0  
Vested (in shares)     (59,000)  
Forfeited (in shares)     (3,000)  
Unvested, at end of period (in shares) 143,000   143,000  
Weighted Average Grant Date Fair Value Per Share [Abstract]        
Unvested, at beginning of period (in dollars per share)     $ 14.77  
Granted (in dollars per share)     0  
Vested (in dollars per share)     15.03  
Forfeited (in dollars per share)     13.00  
Unvested, at end of period (in dollars per share) $ 14.70   $ 14.70  
Grant date fair value of shares vested during the period $ 896   $ 896  
Unrecognized compensation costs of RSU awards 1,881   $ 1,881  
Additional Disclosures [Abstract]        
Vesting period     3 years  
Stock Options [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses $ 1,323 7 $ 2,380 7
Number of Options [Roll Forward]        
Outstanding at beginning of period (in shares)     1,033,000  
Granted (in shares)     975,000  
Forfeited (in shares)     (25,000)  
Exercised, expired (in shares)     0  
Outstanding at end of period (in shares) 1,983,000   1,983,000  
Vested or expected to vest at end of period (in shares) 1,868,000   1,868,000  
Exercisable at end of period (in shares) 223,000   223,000  
Weighted Average Exercise Price [Abstract]        
Outstanding at beginning of period (In dollars per share)     $ 14.72  
Granted (in dollars per share)     7.51  
Forfeited (in dollars per share)     7.77  
Exercised, expired (in dollars per share)     0  
Outstanding at end of period (In dollars per share) $ 11.26   11.26  
Vested or expected to vest at end of period (in dollars per share) 11.12   11.12  
Exercisable at end of period (in dollars per share) 14.32   $ 14.32  
Fair Value Assumptions [Abstract]        
Expected dividend yield     0.00%  
Additional Disclosures [Abstract]        
Weighted average grant date fair value (in dollars per share)     $ 7.51  
Share price (in dollars per share) $ 4.20   $ 4.20  
Intrinsic value of options granted     $ 0  
Compensation Cost Not yet Recognized [Abstract]        
Unrecognized compensation expenses related to non-vested stock options $ 11,352   $ 11,352  
Unrecognized compensation cost, recognition period     2 years 3 months 18 days  
Stock Options [Member] | Minimum [Member]        
Weighted Average Exercise Price [Abstract]        
Granted (in dollars per share)     $ 4.38  
Fair Value Assumptions [Abstract]        
Expected volatility     85.00%  
Expected term (years)     5 years 6 months  
Risk-free interest rate     1.90%  
Stock Options [Member] | Maximum [Member]        
Weighted Average Exercise Price [Abstract]        
Granted (in dollars per share)     $ 8.05  
Fair Value Assumptions [Abstract]        
Expected volatility     95.00%  
Expected term (years)     6 years 1 month 6 days  
Risk-free interest rate     2.60%  
Employee Stock Purchase Plan [Member]        
Share-based Compensation expenses [Abstract]        
Share-based compensation expenses $ 20 $ 0 $ 20 $ 0
Employee Stock Purchase Plan [Abstract]        
Purchase price of common stock as percentage of fair market value     85.00%  
Shares issued under employee stock purchase plan (in shares)     31,393  
Discount value on shares issued under employee stock purchase plan     $ 20