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Stock Option Plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2019
Dec. 31, 2018
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Options granted (in shares)     32,950     629,716 1,375,329
Aggregate intrinsic value of options exercised     $ 2,461        
Compensation expense for share-based awards     $ 262 $ 162 $ 911 $ 535  
Common stock reserved for future issuance (in shares) 28,248,103 28,499,408 28,248,103   28,499,408 28,706,795  
Compensation expensed not yet recognized $ 2,433 $ 2,524 $ 2,433   $ 2,524    
Compensation expensed not yet recognized, period for recognition     3 years 14 days   3 years 5 months 19 days    
ISO              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Exercise threshold as a percentage of fair value of shares 100.00% 100.00% 100.00%   100.00%    
NSO              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Exercise threshold as a percentage of fair value of shares 85.00% 85.00% 85.00%   85.00%    
ISO and NSO              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Option term     10 years   10 years    
Option vesting term     4 years   4 years    
Monthly vesting period     3 years   3 years    
ISO and NSO | Vesting Term One              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Vesting percentage     25.00%   25.00%    
ISO and NSO | 10% Stockholders              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Exercise threshold as a percentage of fair value of shares 110.00% 110.00% 110.00%   110.00%    
Common stock options              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Options granted (in shares)         575,314 1,371,626  
Weighted average grant date fair value (in USD per share)         $ 2.81 $ 0.83  
Fair value of options vested (in USD per share)         $ 569,000 $ 423,000  
Aggregate intrinsic value of options exercised         $ 787 $ 143  
Compensation expense for share-based awards         $ 728 $ 442  
Percent of outstanding shares of common stock 1.00%            
Percent of purchase of price of common stock 85.00%            
Common stock reserved for future issuance (in shares) 434,000   434,000        
Number of additional shares allowable under the plan (in shares) 1,200,000   1,200,000        
Nonemployee options              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Options granted (in shares)         52,960 3,703  
Nonemployee stock-based compensation expense         $ 183 $ 93  
2007 Stock Option Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Shares of common stock reserved for issuance (in shares) 5,488,229 5,488,229 5,488,229   5,488,229    
NeuroCo Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Shares of common stock reserved for issuance (in shares) 0 0 0   0    
Options granted (in shares)   1,442     1,442    
2019 Stock Option Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Shares of common stock reserved for issuance (in shares) 2,317,000   2,317,000        
Percent of outstanding shares of common stock     4.00%        
2019 Stock Option Plan | Maximum              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of additional shares allowable under the plan (in shares) 3,000,000   3,000,000