X0306 4 2021-05-04 0 0001412486 Cocrystal Pharma, Inc. COCP 0001397607 Schinazi Raymond F 1860 MONTREAL ROAD TUCKER GA 30084 0 0 1 0 Common Stock 2021-05-04 4 S 0 575000 2.95 D 7674960 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $2.60 to $3.25, inclusive. The Reporting Person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the ranges set forth in footnote (1) to this Form 4. /s/ Raymond F. Schinazi 2021-05-06