The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adicet Common 007002108 30,885 2,115,385 SH   DFND   2,115,385 0 0
Aeglea Common 00773J103 121 240,500 SH   DFND   240,500 0 0
Cymabay Common 23257D103 385 131,036 SH   DFND   131,036 0 0
eFFECTOR Common 28202V108 6,462 4,822,114 SH   DFND   4,822,114 0 0
Exicure Common 30205M101 594 281,636 SH   DFND   281,636 0 0
Hillevax Common 43157M102 19,929 1,838,486 SH   DFND   1,838,486 0 0
Jasper Common 471871103 10,638 5,628,558 SH   DFND   5,628,558 0 0
Molecular Templates Common 608550109 182 200,000 SH   DFND   200,000 0 0
Nucana ADR 67022C106 2,417 3,333,333 SH   DFND   3,333,333 0 0
Obseva Common H5861P103 141 87,999 SH   DFND   87,999 0 0
Ocugen Common 43358V109 16 7,111 SH   DFND   7,111 0 0
Paratek Common 699374302 1,999 1,041,131 SH   DFND   1,041,131 0 0
Phathom Common 71722W107 12,112 1,435,106 SH   DFND   1,435,106 0 0
Reneo Common 75974E103 5,413 2,073,957 SH   DFND   2,073,957 0 0
Sientra Common 82621J105 1,389 1,673,589 SH   DFND   1,673,589 0 0
Sierra Oncology Common 82640U107 72,277 1,314,127 SH   DFND   1,314,127 0 0
Soleno Common 834203200 3,165 18,022,602 SH   DFND   18,022,602 0 0
Spruce Bio Common E5209E109 3,101 1,792,518 SH   DFND   1,792,518 0 0
Vaxcyte Common 92243G108 90,711 4,168,718 SH   DFND   4,168,718 0 0
Vera Common 92337R101 40,289 2,960,231 SH   DFND   2,960,231 0 0
Verona SPONDS ADR 925050106 10,174 2,457,500 SH   DFND   2,457,500 0 0