The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aeglea Common 00773J103 1,703 240,500 SH   DFND   240,500 0 0
Crispr NAMEN AKT H17182108 21,684 259,599 SH   DFND   259,599 0 0
Cymabay Common 23257D103 947 131,036 SH   DFND   131,036 0 0
Exicure Common 30205M101 12,070 6,977,000 SH   DFND   6,977,000 0 0
Molecular Templates Common 608550109 2,180 200,000 SH   DFND   200,000 0 0
Nucana ADS 67022C106 17,233 3,333,333 SH   DFND   3,333,333 0 0
Obseva Common H5861P103 218 87,999 SH   DFND   87,999 0 0
Ocugen Common 43358V109 2 7,111 SH   DFND   7,111 0 0
Paratek Common 699374302 5,622 1,041,131 SH   DFND   1,041,131 0 0
Personalis Common 71535D106 96,701 4,462,452 SH   DFND   4,462,452 0 0
Phathom Common 71722W107 44,516 1,203,135 SH   DFND   1,203,135 0 0
Protara Common 74371L109 344 20,610 SH   DFND   20,610 0 0
Sientra Common 82621J105 8,129 2,390,843 SH   DFND   2,390,843 0 0
Sierra Oncology Common 82640U107 9,212 876,541 SH   DFND   876,541 0 0
Soleno Common 834203200 25,757 10,302,602 SH   DFND   10,302,602 0 0
Vaxcyte Common 92243G108 205,851 4,168,718 SH   DFND   4,168,718 0 0
Verona SPONDS ADR 925050106 15,335 2,457,499 SH   DFND   2,457,499 0 0