The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aeglea Common 00773J103 1,104 240,500 SH   DFND   240,500 0 0
Chiasma Common 16706W102 1,346 370,671 SH   DFND   370,671 0 0
Crispr NAMEN AKT H17182108 21,952 519,198 SH   DFND   519,198 0 0
Cymabay Common 23257D103 191 131,036 SH   DFND   131,036 0 0
Exicure Common 30205M101 10,186 6,977,000 SH   DFND   6,977,000 0 0
Molecular Templates Common 608550109 2,642 200,000 SH   DFND   200,000 0 0
Obseva Common H5861P103 210 87,999 SH   DFND   87,999 0 0
Ocugen Common 43358V109 2 7,111 SH   DFND   7,111 0 0
Paratek Common 699374302 3,238 1,041,131 SH   DFND   1,041,131 0 0
Personalis Common 71535D106 43,594 5,449,294 SH   DFND   5,449,294 0 0
Phathom Common 71722W107 30,824 1,203,135 SH   DFND   1,203,135 0 0
Artara Common 04300J107 2,620 113,919 SH   DFND   113,919 0 0
Sientra Common 82621J105 4,686 2,390,843 SH   DFND   2,390,843 0 0
Sierra Oncology Common 82640U107 8,590 876,541 SH   DFND   876,541 0 0
Soleno Common 834203200 15,681 6,969,272 SH   DFND   6,969,272 0 0
Verona SPONDS ADR 925050106 3,716 901,943 SH   DFND   901,943 0 0