The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aeglea Common 00773J103 1,835 240,500 SH   DFND   240,500 0 0
Chiasma Common 16706W102 1,835 370,671 SH   DFND   370,671 0 0
Crispr NAMEN AKT H17182108 31,619 519,198 SH   DFND   519,198 0 0
Cymabay Common 23257D103 256 131,036 SH   DFND   131,036 0 0
Exicure Common 30205M101 19,884 6,977,000 SH   DFND   6,977,000 0 0
Molecular Templates Common 608550109 2,796 200,000 SH   DFND   200,000 0 0
Ocugen Common 43358V109 4 7,111 SH   DFND   7,111 0 0
Obseva Common H5861P103 335 87,999 SH   DFND   87,999 0 0
Paratek Common 699374302 4,185 1,041,131 SH   DFND   1,041,131 0 0
Personalis Common 71535D106 59,288 5,449,294 SH   DFND   5,449,294 0 0
Phathom Common 71722W107 37,430 1,203,135 SH   DFND   1,203,135 0 0
Proteon Common 74371L109 879 2,144,517 SH   DFND   2,144,517 0 0
Sientra Common 82621J105 21,326 2,390,843 SH   DFND   2,390,843 0 0
Sierra Oncology Common 82640U107 74 216,667 SH   DFND   216,667 0 0
Soleno Common 834203200 19,932 6,969,272 SH   DFND   6,969,272 0 0
Verona SPONDS ADR 925050106 5,231 901,943 SH   DFND   901,943 0 0