The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aeglea Common 00773J103 1,638 240,500 SH   DFND   240,500 0 0
Avedro Common 05355N109 14,086 719,402 SH   DFND   719,402 0 0
Chiasma Common 16706W102 3,558 478,206 SH   DFND   2,080,595 0 0
Crispr NAMEN AKT H17182108 55,050 1,171,268 SH   DFND   1,171,268 0 0
Cymabay Common 23257D103 937 131,036 SH   DFND   131,036 0 0
Histogenics Common 43358V109 84 426,666 SH   DFND   1,777,778 0 0
Obseva Common H5861P103 985 87,999 SH   DFND   87,999 0 0
Paratek Common 699374302 4,123 1,041,131 SH   DFND   1,041,131 0 0
Personalis Common 71535D106 147,948 5,449,294 SH   DFND   2,017,872 0 0
Proteon Common 74371L109 851 2,017,872 SH   DFND   255,371 0 0
Sientra Common 82621J105 14,704 2,390,843 SH   DFND   2,390,843 0 0
Sierra Oncology Common 82640U107 121 216,667 SH   DFND   1,365,027 0 0
Soleno Common 834203200 12,140 4,669,272 SH   DFND   4,669,272 0 0
Verona SPONDS ADR 925050106 4,537 901,943 SH   DFND   901,943 0 0