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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adaptimmune SPONDS ADR 00653A107 1,375 250,000 SH   DFND   250,000 0 0
Aurinia Pharma Common 05156V102 1,848 252,129 SH   DFND   252,129 0 0
Cascadian Common 14740B606 3,830 925,000 SH   DFND   925,000 0 0
Cellectis SPONDS ADR 15117K103 2,400 100,000 SH   DFND   100,000 0 0
Chiasma Common 16706W102 3,537 2,080,595 SH   DFND   2,080,595 0 0
Crispr NAMEN AKT H17182108 56,641 2,601,814 SH   DFND   2,601,814 0 0
Cymabay Common 23257D103 6,864 1,600,000 SH   DFND   1,600,000 0 0
Dermira Common 24983L104 2,386 70,000 SH   DFND   70,000 0 0
Histogenix Common 43358V109 1,476 888,889 SH   DFND   888,889 0 0
Innocoll SPONDS ADR 45780Q103 586 537,235 SH   DFND   537,235 0 0
Immune Design Common 45252L103 2,378 352,300 SH   DFND   352,300 0 0
Lombard Medical Common G55598109 2,709 3,473,452 SH   DFND   3,473,452 0 0
Novan Common 66988N106 337 53,367 SH   DFND   53,367 0 0
Paratek Common 699374302 25,052 1,301,413 SH   DFND   1,301,413 0 0
Proteon Common 74371L109 3,430 2,017,872 SH   DFND   2,017,872 0 0
Senseonics Common 81727U105 920 516,882 SH   DFND   516,882 0 0
Sientra Common 82621J105 18,450 2,199,012 SH   DFND   2,199,012 0 0