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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adaptimmune SPONDS ADR 00653A107 1,003 250,000 SH   DFND   250,000 0 0
Anthera Common 03674U201 284 437,994 SH   DFND   437,994 0 0
Aurinia Pharma Common 03674U201 890 423,729 SH   DFND   423,729 0 0
Cellectis SPONDS ADR 15117K103 1,691 100,000 SH   DFND   100,000 0 0
Chiasma Common 16706W102 3,953 2,080,595 SH   DFND   2,080,595 0 0
Crispr Common H17182108 52,036 2,601,814 SH   DFND   2,601,814 0 0
Cymabay Common 23257D103 2,720 1,600,000 SH   DFND   1,600,000 0 0
Dermira Common 24983L104 2,122 70,000 SH   DFND   70,000 0 0
Dicerna Common 253031108 973 337,825 SH   DFND   337,825 0 0
Histogenix Common 43358V109 1,440 888,889 SH   DFND   888,889 0 0
Innocoll SPONDS ADR 45780Q103 360 537,235 SH   DFND   537,235 0 0
Immune Design Common 45252L103 1,075 197,300 SH   DFND   197,300 0 0
Lombard Medical Common G55598109 2,032 3,473,452 SH   DFND   3,473,452 0 0
Novan Common 66988N106 5,376 200,000 SH   DFND   200,000 0 0
Paratek Common 699374302 19,977 1,301,413 SH   DFND   1,301,413 0 0
Proteon Common 74371L109 3,632 2,017,872 SH   DFND   2,017,872 0 0
Senseonics Common 81727U105 1,375 516,882 SH   DFND   516,882 0 0
Sientra Common 82621J105 18,692 2,199,012 SH   DFND   2,199,012 0 0