Adaptimmune SPONDS ADR 00653A107 1763 250000 SH DFND 250000 0 0 Anthera Common 05156V102 1375 437994 SH DFND 437994 0 0 Aurinia Pharma Common 03674U201 1531 512036 SH DFND 512036 0 0 Cellectis SPONDS ADR 15117K103 2407 100000 SH DFND 100000 0 0 Cempra Common 15130J109 9287 383935 SH DFND 383935 0 0 Chiasma Common 16706W102 6096 2080595 SH DFND 2080595 0 0 Cymabay Common 23257D103 3104 1600000 SH DFND 1600000 0 0 Dermira Common 24983L104 2367 70000 SH DFND 70000 0 0 Dicerna Common 253031108 5561 945757 SH DFND 945757 0 0 Histogenix Common 43358V109 543 176904 SH DFND 176904 0 0 Innocoll SPONDS ADR 45780Q103 3228 555555 SH DFND 555555 0 0 Immune Design Common 45252L103 1494 197300 SH DFND 197300 0 0 Lombard Medical Common G55598109 3201 3473452 SH DFND 3473452 0 0 Oncogenex Pharma Common 68230A106 195 396104 SH DFND 396104 0 0 Novan Common 66988N106 4032 200000 SH DFND 200000 0 0 Paratek Common 699374302 16918 1301413 SH DFND 1301413 0 0 Proteon Common 74371L109 18383 2017872 SH DFND 2017872 0 0 Regulus Common 75915K101 1080 327350 SH DFND 327350 0 0 Senseonics Common 81727U105 2000 516882 SH DFND 516882 0 0 Sientra Common 82621J105 19769 2199012 SH DFND 2199012 0 0