The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adaptimmune SPONDS ADR 00653A107 2,033 250,000 SH   DFND   250,000 0 0
Anthera Common 03674U201 1,349 437,994 SH   DFND   437,994 0 0
Aurinia Pharma Common 05156V102 1,388 512,036 SH   DFND   512,036 0 0
Cellectis SPONDS ADR 15117K103 2,659 100,000 SH   DFND   100,000 0 0
Cempra Common 15130J109 6,331 383,935 SH   DFND   383,935 0 0
Chiasma Common 16706W102 6,013 2,080,595 SH   DFND   2,080,595 0 0
Cymabay Common 23257D103 2,800 1,600,000 SH   DFND   1,600,000 0 0
Dermira Common 24983L104 2,047 70,000 SH   DFND   70,000 0 0
Dicerna Common 253031108 2,828 945,757 SH   DFND   945,757 0 0
Epirus Biopharma Common 29428P107 4 7,896 SH   DFND   7,896 0 0
Innocoll SPONDS ADR 45780Q103 3,067 555,555 SH   DFND   555,555 0 0
Immune Design Common 45252L103 1,610 197,300 SH   DFND   197,300 0 0
Lombard Medical Common G55598109 3,786 3,473,452 SH   DFND   3,473,452 0 0
Oncogenex Pharma Common 68230A106 400 396,104 SH   DFND   396,104 0 0
Paratek Common 699374302 18,103 1,301,413 SH   DFND   1,301,413 0 0
Proteon Common 74371L109 16,264 2,017,872 SH   DFND   2,017,872 0 0
Regulus Common 75915K101 943 327,350 SH   DFND   327,350 0 0
Senseonics Common 81727U105 2,026 516,882 SH   DFND   516,882 0 0
Sientra Common 82621J105 14,470 2,199,012 SH   DFND   2,199,012 0 0
Tobira Common 88883P101 7,377 589,244 SH   DFND   589,244 0 0