The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adaptimmune SPONDS ADR 00653A107 2,028 250,000 SH   DFND   250,000 0 0
Anthera Common 03674U201 1,577 437,994 SH   DFND   437,994 0 0
Aurinia Pharma Common 05156V102 256 88,307 SH   DFND   88,307 0 0
Cellectis SPONDS ADR 15117K103 2,735 100,000 SH   DFND   100,000 0 0
Cempra Common 15130J109 6,723 383,935 SH   DFND   383,935 0 0
ChemoCentryx Common 16383L106 533 215,000 SH   DFND   215,000 0 0
Chiasma Common 16706W102 19,037 2,080,595 SH   DFND   2,080,595 0 0
Cymabay Common 23257D103 2,160 1,600,000 SH   DFND   1,600,000 0 0
Dermira Common 24983L104 1,448 70,000 SH   DFND   70,000 0 0
Dicerna Common 253031108 5,060 945,757 SH   DFND   945,757 0 0
Epirus Biopharma Common 29428P107 21 7,896 SH   DFND   7,896 0 0
Innocoll SPONDS ADR 45780Q103 4,667 555,555 SH   DFND   555,555 0 0
Lombard Medical Common G55598109 3,751 3,473,452 SH   DFND   3,473,452 0 0
Oncogenex Pharma Common 68230A106 271 396,104 SH   DFND   396,104 0 0
Paratek Common 699374302 19,703 1,301,413 SH   DFND   1,301,413 0 0
Proteon Common 74371L109 15,558 2,017,872 SH   DFND   2,017,872 0 0
Regulus Common 75915K101 2,265 327,350 SH   DFND   327,350 0 0
Sientra Common 82621J105 15,041 2,199,012 SH   DFND   2,199,012 0 0
Tobira Common 88883P101 4,785 589,244 SH   DFND   589,244 0 0