The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Anthera Common 03674U201 2,667 437,994 SH   DFND   437,994 0 0
Cempra Common 15130J109 10,685 383,935 SH   DFND   383,935 0 0
Chemocentryx Common 16383L106 1,296 215,000 SH   DFND   215,000 0 0
Chiasma Common 16706W102 41,362 2,080,595 SH   DFND   2,080,595 0 0
Cymabay Common 23257D103 3,072 1,600,000 SH   DFND   1,600,000 0 0
Dermira Common 24983L104 1,624 70,000 SH   DFND   70,000 0 0
Dicerna Common 253031108 7,755 945,757 SH   DFND   945,757 0 0
Epirus Biopharma Common 29428P107 35 7,896 SH   DFND   7,896 0 0
Flex Pharma Common 33938A105 120 10,000 SH   DFND   10,000 0 0
Innocoll Common 45780Q103 6,689 555,555 SH   DFND   555,555 0 0
Lombard Medical Common G55598109 12,331 3,473,452 SH   DFND   3,473,452 0 0
Oncogenex Pharma Common 68230A106 1,334 603,740 SH   DFND   603,740 0 0
Paratek Common 699374302 24,701 1,301,413 SH   DFND   1,301,413 0 0
Proteon Common 74371L109 27,423 2,017,872 SH   DFND   2,017,872 0 0
Regulus Common 75915K101 2,138 327,350 SH   DFND   327,350 0 0
Sientra Common 82621J105 22,320 2,199,012 SH   DFND   2,199,012 0 0
Tobira Spons ADR 88883P101 5,657 589,244 SH   DFND   589,244 0 0