The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Amarin Spons ADR 023111206 8,815 8,087,486 SH   DFND   8,087,486 0 0
Anthera Common 03674U201 832 437,994 SH   DFND   437,994 0 0
Cempra Common 15130J109 7,829 714,285 SH   DFND   714,285 0 0
Dicerna Common 253031108 15,038 1,182,196 SH   DFND   1,182,196 0 0
Hyperion Common 44915N101 1,576 62,500 SH   DFND   62,500 0 0
Lombard Medical Common G55598109 25,647 3,352,544 SH   DFND   3,352,544 0 0
Oncogenex Pharma Common 68230A106 1,600 603,740 SH   DFND   603,740 0 0
Portola Common 737010108 23,528 930,682 SH   DFND 1 930,682 0 0
Prosensa Common N71546100 49,748 5,901,267 SH   DFND 1 5,901,267 0 0
Regulus Common 75915K101 2,242 327,350 SH   DFND   327,350 0 0
Supernus Common 868459108 24,469 2,815,777 SH   DFND 1 2,815,777 0 0
Epirus Biopharma Common 29428P107 56 7,896 SH   DFND   7,896 0 0
Zogenix Common 98978L105 2,686 2,335,218 SH   DFND 1 2,335,218 0 0